COPPER SALICYLATE
A Potent Inflammation Fighter
and Rejuvenator
By Walter Last
Copper is an essential
trace mineral. All tissues of the body need it for normal metabolic functions.
It is excellent for reducing inflammations, strengthening connective tissue,
restoring hair colour and the oxidative energy metabolism as well as fighting
parasites and cancer, and it may even improve brain and liver functions.
If you give animals a
choice between drinking normal water and water in which a copper pipe has been
immersed, they will reportedly prefer the high copper water. This helps to keep
them free of parasites. Copper armbands are well known to reduce arthritis.
Copper serum levels are elevated up to threefold above normal with
inflammations and with many chronic and infectious diseases, apparently because
the body mobilizes all tissue stores of copper to fight the condition. During
remissions the copper blood levels return to normal.
Copper Biochemistry
In the blood copper is transported
by the proteins ceruloplasmin and copper-albumin,
while inside cells it is stored as proteins called metallothioneins,
or used as copper containing enzymes. Copper enzymes include:
· cytochrome C oxidase needed for oxidative
energy production within cells;
· superoxide dismutase, a strong antioxidant
for protection against free radicals;
·
dopamine hydroxylase for producing catecholamine neurotransmitters
such as dopamine and noradrenaline. A copper
enzyme is also needed for the synthesis of adrenalin (epinephrine);
· lysyl oxidase for the production of connective
tissue such as collagen and elastin for healthy skin,
bones, joints and blood vessels;
· tyrosinase for pigmentation of hair and skin;
· clotting factor V, a blood clotting factor,
and
· ceruloplasmin, an antioxidant needed for the iron
metabolism.
Sometimes there is too
much inorganic copper in supplements or drinking water as from acid water
flowing through copper pipes. It can then accumulate in the body and lead to
toxicity symptoms with signs of zinc deficiency, over-stimulation, psychosis
and liver damage. But normally only as much copper is absorbed and retained as
can be incorporated into these copper transport, storage and enzyme systems. The liver is the main storage organ for
copper. Excess copper is normally excreted with the bile.
A deficiency of
transport and storage proteins can lead to copper deficiency in the same way as
low dietary intake. Copper deficiency is widespread. I regard copper deficiency
as the main cause of grey or white hair. For adults a daily intake of 2-3 mg is generally recommended but intakes
of less than 1 mg are very common. Unfortunately there is no reliable test to
see if we have enough copper. Blood tests are totally unreliable, and also hair
tests are uncertain.
Supplementation with high
amounts of vitamin C (e.g. 1000 mg) or zinc (e.g. 30 mg) during a meal tends to
prevent the absorption of copper. Therefore supply additional copper with meals
when these are not being used. However copper salicylate may not to be affected
by vitamin C and zinc.
Prolonged cortisone treatment
has been shown to increase the body's excretion of copper and may lead to
copper deficiency. This may cause various health problems, including the
development or acceleration of osteoporosis, scoliosis, skeletal abnormalities
and susceptibility to fractures.
Copper and Diseases
Adequate copper intake is
essential for normal functioning of the immune system. The immune system is
significantly weakened at marginal copper levels that do not even affect tissue
copper levels or the activity of copper enzymes. A weakening of the immune
system could be detected as soon as one week after starting a diet low in
copper. Conversely, the addition of sufficient copper improved the suppressed
immune system within one week (1). All forms of copper compounds are also
effective fungicides.
Copper deficiency has been shown
to have a strong role in anemia, arthritis, cancer, cardiovascular diseases,
epilepsy, fat metabolism, free radical damage, immune functions, inflammatory
diseases, osteoporosis, and thyroid function (underactive). Wilson's disease is
a rare genetic condition with a lack of ceruloplasmin,
low serum copper levels, and high copper stores in the liver.
Deficiency symptoms
include anemia, bone disorders, defective spinal
cord, hair greying and hair becoming fine and straight, losing its curl,
infertility; weak connective tissue as
evidenced by heart problems such as enlarged heart, weak aorta with holes and
ruptures, aneurisms, varicose veins, wrinkling skin, and hernias. Copper deficiency greatly increases the lipid
peroxidation of lipoproteins and cardiovascular
tissue. It causes high
cholesterol levels, and heart
attack victims have low copper levels in the heart.
With atherosclerosis serum
copper levels are high but levels in the aorta and liver are low. Copper
supplementation leads initially to even higher serum copper levels but then to
a normalization of all copper values as well as significant improvements in
cholesterol levels and atherosclerosis.
With cancer copper serum levels
behave similar to those described for atherosclerosis. Various studies show a
beneficial effect of copper on cancer. However, if growing tumours are present, then
copper is needed to form new blood vessels. Therefore one form of cancer
therapy creates artificial copper deficiency by removing copper with a
molybdenum compound, and high amounts of zinc may be used to prevent the
absorption of copper. It has now been shown that in the long-term this
so-called anti-angiogenesis therapy does more harm than good by stressing
tumours and inducing them to spread (2).
The main metabolic
defect of cancer cells, according to Dr Johanna Budwig and other researchers,
is a deficiency of the enzyme cytochrome oxidase. This causes a blockage in the
cellular respiration or oxidative energy production of the affected cells.
Cytochrome oxidase is a copper dependent enzyme and additional copper might be
beneficial. In the final stages of this oxidative energy production cytochrome
oxidase transfers electrons to copper (II) and iron (III) to form copper (I)
and iron (II). In the last step these electrons are then transferred to oxygen,
which now can attract hydrogen ions to form water. In cancer cells this
electron transfer is blocked and energy is inefficiently produced by converting
glucose into lactic acid.
Due to copper deficiency this electron transfer is defective in Menkes disease, a genetic disorder of early childhood. This
is sometimes called Menkes kinky hair disease because
such babies have very fragile hair; they also have abnormal brain development
and a low body temperature. They are very floppy, lack energy and usually will
not survive beyond 3 years of age.
Australian soils are generally copper deficient, and the importance of
copper for development was discovered in
Copper Salicylate Complexes
Copper complexes are highly
effective anti-inflammatory agents. In addition, copper complexes have shown
great potential in the treatment of numerous chronic diseases. These include,
in addition to inflammatory diseases, gastrointestinal ulcers, cancers,
epilepsy, and diabetes. Commonly
copper complexes are related to salicylic acid. The main copper complex is copper salicylate.
Another commonly used complex is
copper aspirinate, the copper complex of aspirin,
which is acetyl-salicylic acid. However, copper salicylate seems to work better
than copper aspirinate. In addition copper ascorbate has strong
anti-viral properties. Copper salicylate is remarkably stable and does not
change the chemistry of the blood or liver as most other copper supplements do
(3).
Dr John R.J. Sorenson
at the
The therapeutic potency
and safety of the copper complexes of aspirin (acetyl-salicylic acid) and
salicylic acid is much better than for aspirin itself or for other copper
compounds such as copper acetate. These complexes are 5 to 8 times more
effective than aspirin but less toxic. The therapeutic index (the margin
between effectiveness and toxic effects) has been stated as being significantly
greater than for other anti-inflammatory drugs (4).
While aspirin and other
anti-inflammatory drugs cause or aggravate ulcers and gastro-intestinal
bleeding and distress, the copper complexes have a better ulcer-healing effect
than commonly used anti-inflammatory ulcer drugs. Harmful effects of aspirin,
salicylic acid and similar drugs apparently arise because they bind copper in
the stomach and intestines wall and cause a localised copper deficiency in
these tissues. This then causes connective tissue disintegration with bleeding
and ulcers. Copper salicylate supplies the necessary copper in a useable form
to heal these lesions. I believe that people who are allergic to salicylates
are mainly reacting because of copper deficiency.
Because copper
salicylate cannot be patented and is too cheap anyway, it is not widely used.
It is much more profitable to first sell drugs that cause ulcers and then sell
ulcer drugs. However, there exist several patents regarding the application of
salicylates to the skin in combination with other ingredients.
Salicylates are a common ingredient of many fruits and vegetables but recently it has been discovered that they are also produced in the human and animal body. A researcher stated: "This simple organic chemical is, we propose, likely to become increasingly recognized as an animal bio-regulator, perhaps in a class of its own"(5).
The copper-zinc enzyme
Superoxide Dismutase (SOD) is one of the most important antioxidants and
inflammation fighters produced in the body to protect cells and bio-molecules
from oxidation damage by free-radicals. Many copper complexes, and in
particular copper salicylate, demonstrate SOD activity. For this reason they
have sometimes been called ‘SOD-mimetics’
because they protect cells in a similar way as SOD. Furthermore the great
stability and wide-ranging health effects of copper salicylate suggest that it
may also function in the body as a quasi transport and storage molecule.
Glutathione is another important
cellular antioxidant. Copper salicylate has a positive effect on the
glutathione status of the liver, and it has been found that this could be
achieved with oral or topical application (3).
Stress is a main factor in
activating granulocytes, immune cells that cause inflammation, and are largely
responsible for the symptoms of autoimmune diseases (6). Copper salicylate
complexes have been found to control the metabolic activation of granulocytes
(4).
A copper complex of
histamine has been shown to be the active form of histamine. Life-threatening
allergic reactions due to histamine overactivity can be treated with salicylic
acid, which chelates the copper and inactivates the
histamine (4).
Cancer and Epilepsy
In addition copper
salicylate has also good anti-cancer, anti-tremor and anti-convulsive
properties suitable for treatment of epilepsy and possibly Parkinson's disease.
After the liver the brain is the second-highest copper-containing organ. There
are at least 6 important copper-dependent enzymes in the brain.
A feature of severe
copper deficiency is degeneration of the central nervous system. Lambs born to
ewes on copper deficient pastures have tremors and ataxia which can be
prevented with copper. With epilepsy serum copper levels are high but brain
copper levels are low. Children with severe copper deficiency constantly have
convulsive seizures. Many copper complexes such as copper salicylate have good
anti-epileptic properties without the many and often severe side-effects of
conventional anti-epileptic drugs (4).
In experiments copper
salicylate prevented chemically induced skin cancers. A single application
resulted in a 55% reduction in experimental animal tumours within 20 weeks (3).
Another study has shown that
there is a relationship between aortic aneurism and malignancy, and this is
probably due to copper deficiency (1).
Elevated serum copper levels typical for inflammatory diseases are also present with cancer. With remission serum copper levels usually return to normal while patients who do not respond to therapy or surgery have persistently elevated serum copper level. Tumor cells have decreased SOD activity and copper salicylate complexes show anti-cancer, anti-carcinogenic, and anti-mutagenic effects. There is even experimental evidence that copper complexes can cause established tumor cells to re-differentiate into normal cells and it has been suggested that "...the future use of copper complexes to treat neoplastic diseases has some exciting possibilities" (1).
Inflammatory and Autoimmune Diseases
Inflammatory and autoimmune
diseases are associated with higher serum copper levels and lover tissue copper
levels than normal. Copper complexes have lower toxicity and stronger anti
-inflammatory activity than their parent compounds. This means, for instance,
copper salicylates has much stronger anti-inflammatory effects than either
common copper compounds or salicylic acid or for that matter other
anti-inflammatory drugs.
Dr Werner Hangerter,
head of medicine at the
Also neuromuscular
problems such as sciatica, neuralgia and cervical spine-shoulder problems
responded very well as did Sarcoidosis. Even short-term treatment of rheumatoid
arthritis resulted in long-term remissions or improvements. Objective measures
of improvement were remission of fever, increased joint mobility, decreased
swelling, and normalisation of erythrocyte sedimentation rate (3, 4).
Wearing copper
bracelets is a time-tested anti-inflammatory treatment but the amount of copper
dissolved with the sweat is relatively low. In contrast, copper salicylates
were found to be the best copper complex for the treatment of arthritic pain
(3, 4).
Prion diseases such as Creutzfeldt-Jakob
or "mad cow" disease, and also Alzheimer’s and Parkinson’s
disease are related to
the accumulation of wrongly folded and entangled prion
proteins. It has now been shown that this may be due to a copper deficiency in
the brain, and that copper stabilises prions and
helps them to fold correctly (7).
In contrast to the
disinterest of drug companies there is much interest in the research
community in copper complexes as anti-inflammatories and anti-arthritics as
evidenced by a large number of reviews and symposia in recent years. This
research shows that copper complexes have strong anti-inflammatory activity in
numerous models of inflammation (1).
Skin and Connective Tissue
Old, wrinkling and sagging skin is one of the signs of copper deficiency. Expensive copper peptides are being sold for the improvement of aging skin. In addition there is also much interest in salicylic acid as a skin rejuvenator. Commonly this has been used for short periods in rather concentrated form, but in 1998 Proctor & Gamble has patented the application on the skin of low dose salicylic acid and salicylates (including copper salicylate) as long-term treatment to prevent, reduce or manage aging skin and wrinkles (8).
The elastic fibers of arteries and other connective tissue need copper for tensile strength. Common examples of weak connective tissue are hernias, varicose veins and aneurisms. Aneurisms are ballooning arteries with very thin walls that easily burst. Albert Einstein and Paavo Aerola (pioneering naturopath and nutritionist) died of ruptured cerebral aneurisms, many individuals with white hair died of abdominal aneurisms. About 5% of autopsied Americans died of ruptured aneurisms, and another 40% have aneurisms that have not yet ruptured (www.american-nutrition.com/ba.html).
An interesting story in regard to aneurisms has been told by Dr Joel Wallach. In 1957 the US Department of Agriculture introduced a "wonder food pellet" for turkeys, guaranteed to grow them faster, bigger and fatter. But that year half of the entire nation's flock of turkeys died of ruptured aortic aneurysms. Analysis showed copper deficiency. The next year copper content of the feed was doubled, and no more turkeys died from ruptured aortic aneurysms (9).
Osteoarthritis is primarily a connective tissue
disease and any inflammation may be caused by joints rubbing together without
sufficient protection. Therefore, response to copper salicylate may be less
dramatic than with rheumatoid arthritis, take longer to eventuate and require
additional co-factors such as MSM, N-Acetyl Glucosamine, fish oils and various
vitamins and minerals.
Restoring Hair Colour
Hair
is coloured by the production of melanin in the hair bulbs. There are two kinds of melanin, eumelanin which colours the hair
brown to black, and pheomelanin that makes it
yellow-blond to red. Different combinations of these two kinds of melanin
determine then the exact colour and shade of the
hair.
Gray
or grey hair results when insufficient nutrients are supplied to the scalp to
maintain normal melanin production in hair cells called melanocytes. Several nutrients are responsible
to convert the amino acid tyrosine into melanin. The most common deficiency is
with copper.
A
convincing demonstration has been conducted with black sheep. When their feed
was alternated several times containing high and low amounts of copper, they
developed alternating black and white coloured bands in their wool; also the
curliness was reduced when copper was low (10).
Grey
hair contains much less copper, magnesium and calcium than naturally coloured
hair. It is not clear if high copper hair levels due to high intake of
inorganic copper can be used for melanin production but I assume that it cannot
be used. To restore hair colour I regard it as most useful to rub diluted
copper salicylate solution directly into the scalp but additional oral intake
will be helpful.
Next
in effectiveness seems to be para-amino benzoic acid
or PABA, which is related to the B group of vitamins. Generally PABA has been
effective in 10 -25% of cases to darken gray or white hair; after stopping
application the colour tends to fade again after several weeks. In clinical
trials amounts from 400 mg up to 15 g of oral PABA have been used daily. PABA,
used orally or topically, is also a natural sunscreen.
PABA
itself is not water-soluble but may be dissolved by adding about one-third of
bicarbonate to PABA suspended in water. Use about half a teaspoon of PABA.
After some fizzing the water will clear and the solution may now be rubbed into
the scalp. Additional PABA may be taken internally with meals, but again I
regard the direct application as more effective. If available you may buy
directly the water-soluble potassium or sodium salts of PABA.
Other
nutrients required to maintain or restore natural hair colour are the B
vitamins pantothenic acid, folic acid (in green leaves) and biotin (highest in
egg yolk), and the quasi B vitamin inositol. Inositol stabilises cell
membranes. This protects the hair bulbs and helps to keep the hair moist and so
darkens its colour; severe deficiency may cause baldness. Zinc may be required
in addition as well as iodine and sufficient calcium and magnesium. Overacidity
causes mineral deficiency and premature gray hair.
Another
cause of fading hair colour is chronic stress. This may be due to emotional
stress or to antioxidant deficiency. In the normal metabolism free radicals and
hydrogen peroxide are being formed. These need to be detoxified otherwise the
melanin-producing enzymes are being damaged. In addition to copper salicylate a
high antioxidant intake can avoid this problem (11).
From
this it also follows that regularly applying oxidants to the scalp as in the
form of chlorinated water will lead to premature greying, and also seems to
contribute to male-pattern baldness. Also drinking chlorinated water or cooking
in it, or frying, all increase the ingestion of oxidized products and
contribute to early greying. Hair colouring damages the hair, and it may then
take longer for a natural colour to reappear. It is not clear if and to what
degree white hair can regain some natural colouring; this may depend very much
on additional measures to improve overall vitality and blood circulation to the
scalp.
There is much anecdotal evidence that increased blood circulation to the scalp can restore hair colour. This may be done by frequently keeping the head lower than the heart, such as with inversion equipment or slant boards, or by rubbing irritating substances into the scalp such as a solution of cayenne or some aromatic oils.
How to Use Copper Salicylate
The amount and mode of
application of copper salicylate depends very much on the problem that is to be
treated. With most conditions an oral dose of 40 to 60 mg of copper salicylate
may be combined with an external or topical application of the same amount.
Orally it should be taken during a meal that does not contain supplements of
zinc or vitamin C. Always increase high-dose supplements or remedies gradually.
Generally it is much
more effective to apply copper salicylate directly to the site of the problem,
rubbing a suitable solution into an arthritic joint, onto a skin or muscle
inflammation, ulcerated leg, aging skin or graying
hair. Copper salicylate dissolves in water and it may be applied in this way.
However, to penetrated the skin it should be kept moist for an extended period
or combined with a suitable carrier.
When rubbing it on the
skin or around a joint you may, for instance, mix the copper salicylate with
some magnesium oil which then keeps the area moist for a long time, just guard
against accidentally rubbing it off, or cover with a cloth. Another possibility
is to apply it together with aloe vera gel. Also MSM helps to soften the skin
and is also beneficial for most conditions anyway.
The most effective
carrier is dimethyl sulfoxide
or DMSO, a liquid that is a close relative of the crystallised MSM. Like MSM,
it is an active sulphur compound and has corresponding healing qualities,
especially for connective tissue. A disadvantage of DMSO is its garlic smell
but compared to an autoimmune disease that may be a lesser problem.
You may mix copper
salicylate with one or several of the indicated ingredients and apply them
together in one application. Alternatively, you may rub first some copper
salicylate solution onto the skin. After it has partly dried you may rub a
small amount of magnesium oil on, and finally some Aloe vera, dissolved MSM or
DMSO.
For
applications to maintain or restore your hair colour you may dilute copper
salicylate with a sufficient amount of water to thoroughly moisten the whole
scalp and possibly the beard. You can keep these moist for longer by following
up with a solution of neutralised PABA. Afterwards pat the scalp and skin and
keep the head low for a minute to increase the blood circulation.
After
your problem has cleared up or as a general maintenance dose you may use 20 to
30 mg of copper salicylate once a day with a suitable meal or apply it to the
skin or hair several times a week. For a source of supply see www.strideintohealth.com.
The
Schweitzer Formula
In
addition to copper salicylate complexes also a salicylate complex with zinc and
boron is a good healing remedy. This has been called the Schweitzer Formula,
and is formed from zinc (oxide or carbonate), boron (boric acid) and salicylic
acid. It has been used as an antibiotic, disinfectant, fungicide, and
anti-inflammatory agent.
The Schweitzer Formula
supposedly was developed 1915 in
To make the Schweitzer
Formula dissolve 9.2 g of salicylic acid, 2.1 g of boric acid and 2.7 g of zinc
oxide or 4 g of zinc carbonate in 2 litres of hot water. You may get these
ingredients from a pharmacist or supplier of fine chemicals and have these
quantities weight out. However, it is sufficient to use approximate amounts.
You may use 2 level teaspoons of salicylic acid and half a teaspoon each of
boric acid and zinc oxide or one level teaspoon of zinc carbonate.
Use distilled or
de-ionised water and a non-metal container. Heat for about an hour, and stir
occasionally with a non-metal spoon until no more of the zinc oxide or zinc
carbonate at the bottom of the container dissolves. Then decant or filter into
a glass container and store in a dark and cool place. Any surplus of zinc oxide
or carbonate that remains undissolved shows that all the boric acid and
salicylic acid have been used up.
Originally Schweitzer
Formula was sold as crystals. If you do want to crystallise the complex, then
let the water evaporate very slowly in a flat non-metal tray covered with fine
gauze. As a general rule, the slower the crystallisation, the bigger the
crystals. Therefore, keep the tray undisturbed in a cool place. For quick
crystallisation and smaller crystals you may expose the tray to direct
sunlight. For use you may then dissolve the crystals again in 2 litres of hot
water.
You may take this at
the ratio of one tablespoon daily. The long-term use of copper or zinc should
be balanced by using the other mineral as well. If internal remedies are used
then zinc and copper should be taken with separate meals. As with copper
salicylate I believe that also zinc-boron salicylate complex is safer and more
effective than the long-term use of aspirin or other anti-inflammatory drugs.
Schweitzer Formula in
high amounts has been used extensively in the healing system of Body
Electronics. One tablespoonful of Schweitzer contains about 15 mg of zinc, 15
mg of boric acid or 2.5 mg of boron, and 70 mg of salicylic acid. As with
copper salicylate, I believe that individuals sensitive to salicylates in food
may not negatively react to Schweitzer Formula but that may need to be
individually tested.
References
(1)
Gissen
A.S.: Copper: The Maligned Mineral. This article appeared first in the
April-July/August, 1994 issues of VRP's Newsletter,
now at www.oralchelation.com/technical/copper1.htm.
(2)
Moss, R.: Shadow Falls on Anti-Angiogenic Drugs. Cancer Decisions Newsletter March 15,
2009, http://www.cancerdecisions.com/031509.html
and http://www.cancerdecisions.com/032209.html
(3)
Bland, J.: Copper Salicylates and Complexes in
Molecular Medicine. Int Clin
Nutr Review 4, 3, 130-134, 1984.
(4)
Sorenson J.R.J.: Copper
Chelates as possible Active Metabolites in the Antiarthritic and Antiepileptic Drugs. J Applied
Nutrition 32, 1&2, 4-25, 1980.
(5)
SCIENCE BLOG 2008-12-22: New
evidence that people make aspirin's active principle; http://www.scienceblog.com/cms/new-evidence-people-make-aspirins-active-principle-salicylic-acid-18065.html
and http://portal.acs.org/portal/acs/corg/content.
(6)
Abo T.: Your Immune
Revolution. Koroko Publ. N.Y. 2007.
(7)
SCIENCE BLOG 2009, June 25: A penny for your prions;
http://www.scienceblog.com/cms/penny-your-prions-22656.html; also Hodak, M. and Chisnell, R.: Cu2+ Binding to the Prion
Protein: Functional Implications and the Role of Copper. Online publication
in Proceedings of the National Academy of Sciences, June 22, 2009,
(8)
US Patent 5776917 - Compositions for regulating skin wrinkles and/or skin
atrophy - www.patentstorm.us/patents/5776917.html.
(9)
Wallach, J.: Dead
Doctors Don’t Lie. A widely distributed audio tape that was later
followed by a book with the same title, see http://www.wallachonline.com/dead_doctors.htm.
(10)
Adams, R. and
Murray. F.: Minerals: Kill or Cure?
Larchmont Books, NY 1974.
(11)
ABC News in
Science: Grey hair? Blame the bleach. 4 March 2009, http://www.abc.net.au/science/articles/2009/03/04/2506240.htm.